Key Takeaways Early detection of metabolic syndrome in lipoedema stage 3–4 is important, as the condition frequently obscures conventional red flags and postpones diagnosis. Major risk factors such as insulin resistance, dyslipidemia, hypertension, central obesity, and chronic inflammation can greatly exacerbate both lipoedema and health if unmanaged. Hormonal imbalances, vascular impairment, and genetic predispositions contribute […]